Endocrine Abstracts

Pancreatic islets are susceptible to hypoxia during isolation, culture, and transplantation. An intervention that protects against hypoxia while preserving β-cell function will improve islet quality. Adrenaline suppresses insulin secretion and oxygen consumption in pancreatic islets. These findings suggest that adrenergic action creates metabolic quiescence in β-cells. Our objective was to determine whether adrenaline is protective during hypoxic culture in an insuli...